MET overexpression and amplification were further assayed centrally using tissue IHC (n=81), tissue NGS (n=117 Foundation Medicine), and ctDNA NGS (n=199 Guardant Health). Informative central MET FISH screening/confirmation results were generated for 254 consented patients. During screening, MET testing (central, or local with central confirmation) was performed on tumor tissue collected after the most recent therapy. In the TATTON study (NCT02143466), the combination of osimertinib and savolitinib (AZD6094, HMPL-504, volitinib), a potent and selective MET-TKI, has demonstrated encouraging anti-tumor activity in patients with NSCLC and MET-driven EGFR-TKI resistance. Thus, there is an urgent need to better understand the reliability of these assays for the detection of MET-driven EGFR-TKI resistance in NSCLC. Previous studies have used a variety of technologies (FISH, IHC, NGS, ctDNA) with mixed success in identifying MET-driven tumors. Amplification of MET occurs in ~20% of EGFR-TKI resistant tumors. As a CAD Manager and Senior Civil Designer I frequently get the request saying “Sam, can you convert this drawing I don’t have AutoCAD 2020?” My answer is simple, “Sure, I can do that”.EGFR-TKIs like osimertinib are widely used to treat advanced EGFR-mutant NSCLC, however tumors inevitably acquire resistance. Then I ask the user “Have you ever tried DWG TrueView?” DWG Trueview has been labeled as a drawing viewer for.
DWG files but what people do not realize that it also contains a built in drawing convert program.
You can install DWG TRUEVIEW 2020 and compare drawing viewers here. Many project managers and senior team members simply need to view the drawing files without having the cost of a full license of AutoCAD.įigure 1: DWG Trueview 2020 Splash screenĪpproximately every three years AutoCAD changes the. dwg file format and older versions of the software are incompatible with the new versions. Table 1 shows the File format the the AutoCAD Release that is compatible with that format. Many years ago some of us remember Autodesk had a separate program named DWG True Convert. The purpose of that was to simply convert. Since DWG Trueview 2010 Autodesk has included DWG Convert within DWG Trueview.
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